Unbiased screen for interactors of leucine-rich repeat kinase 2 supports a common pathway for sporadic and familial Parkinson disease
Identifieur interne : 000874 ( Main/Exploration ); précédent : 000873; suivant : 000875Unbiased screen for interactors of leucine-rich repeat kinase 2 supports a common pathway for sporadic and familial Parkinson disease
Auteurs : Alexandria Beilina ; Iakov N. Rudenko ; Alice Kaganovich ; Laura Civiero [Italie] ; Hien Chau ; Suneil K. Kalia ; Lorraine V. Kalia [Canada] ; Evy Lobbestael [Belgique] ; Ruth Chia ; Kelechi Ndukwe ; Jinhui Ding ; Mike A. Nalls ; Maciej Olszewski ; David N. Hauser ; Ravindran Kumaran ; Andres M. Lozano ; Veerle Baekelandt [Belgique] ; Lois E. Greene ; Jean-Marc Taymans [Belgique] ; Elisa Greggio [Italie] ; Mark R. CooksonSource :
- Proceedings of the National Academy of Sciences of the United States of America [ 0027-8424 ] ; 2014.
Abstract
Understanding loci nominated by genome-wide association studies (GWASs) is challenging. Here, we show, using the specific example of Parkinson disease, that identification of protein–protein interactions can help determine the most likely candidate for several GWAS loci. This result illustrates a significant general principle that will likely apply across multiple diseases.
Url:
DOI: 10.1073/pnas.1318306111
PubMed: 24510904
PubMed Central: 3932908
Affiliations:
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Rudenko</name><affiliation><nlm:aff id="aff1">Cell Biology and Gene Expression Section,</nlm:aff></affiliation></author><author><name sortKey="Kaganovich, Alice" sort="Kaganovich, Alice" uniqKey="Kaganovich A" first="Alice" last="Kaganovich">Alice Kaganovich</name><affiliation><nlm:aff id="aff1">Cell Biology and Gene Expression Section,</nlm:aff></affiliation></author><author><name sortKey="Civiero, Laura" sort="Civiero, Laura" uniqKey="Civiero L" first="Laura" last="Civiero">Laura Civiero</name><affiliation wicri:level="1"><nlm:aff id="aff4">Department of Biology,<institution>University of Padova</institution>, 35131 Padua,<country>Italy</country>;</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Chau, Hien" sort="Chau, Hien" uniqKey="Chau H" first="Hien" last="Chau">Hien Chau</name><affiliation><nlm:aff id="aff5">Division of Brain, Imaging, and Behaviour Systems Neuroscience,</nlm:aff><wicri:noCountry code="subfield">and Behaviour Systems Neuroscience</wicri:noCountry></affiliation></author><author><name sortKey="Kalia, Suneil K" sort="Kalia, Suneil K" uniqKey="Kalia S" first="Suneil K." last="Kalia">Suneil K. Kalia</name><affiliation><nlm:aff wicri:cut=", and" id="aff6">Division of Neurosurgery, Department of Surgery</nlm:aff><wicri:noCountry code="subfield">Department of Surgery</wicri:noCountry></affiliation></author><author><name sortKey="Kalia, Lorraine V" sort="Kalia, Lorraine V" uniqKey="Kalia L" first="Lorraine V." last="Kalia">Lorraine V. Kalia</name><affiliation wicri:level="1"><nlm:aff id="aff7">Division of Neurology, Department of Medicine, Toronto Western Research Institute, University Health Network,<institution>University of Toronto</institution>, Toronto, ON,<country>Canada</country> M5T 2S8;</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Lobbestael, Evy" sort="Lobbestael, Evy" uniqKey="Lobbestael E" first="Evy" last="Lobbestael">Evy Lobbestael</name><affiliation wicri:level="1"><nlm:aff id="aff8">Laboratory for Neurobiology and Gene Therapy,<institution>KU Leuven</institution>, 3000 Leuven,<country>Belgium</country>;</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Chia, Ruth" sort="Chia, Ruth" uniqKey="Chia R" first="Ruth" last="Chia">Ruth Chia</name><affiliation><nlm:aff id="aff1">Cell Biology and Gene Expression Section,</nlm:aff></affiliation></author><author><name sortKey="Ndukwe, Kelechi" sort="Ndukwe, Kelechi" uniqKey="Ndukwe K" first="Kelechi" last="Ndukwe">Kelechi Ndukwe</name><affiliation><nlm:aff id="aff1">Cell Biology and Gene Expression Section,</nlm:aff></affiliation></author><author><name sortKey="Ding, Jinhui" sort="Ding, Jinhui" uniqKey="Ding J" first="Jinhui" last="Ding">Jinhui Ding</name><affiliation><nlm:aff wicri:cut=", and" id="aff2">Computational Biology Core, Laboratory of Neurogenetics</nlm:aff><wicri:noCountry code="subfield">Laboratory of Neurogenetics</wicri:noCountry></affiliation></author><author><name sortKey="Nalls, Mike A" sort="Nalls, Mike A" uniqKey="Nalls M" first="Mike A." last="Nalls">Mike A. Nalls</name><affiliation><nlm:aff id="aff3">Molecular Genetics Section,<institution>National Institute on Aging/National Institutes of Health</institution>, Bethesda,<addr-line>MD</addr-line> 20892;</nlm:aff></affiliation></author><author><name sortKey="Olszewski, Maciej" sort="Olszewski, Maciej" uniqKey="Olszewski M" first="Maciej" last="Olszewski">Maciej Olszewski</name><affiliation><nlm:aff wicri:cut="; and" id="aff9">Laboratory of Cellular Physiology,<institution>National Heart, Lung and Blood Institute/National Institutes of Health</institution>, Bethesda,<addr-line>MD</addr-line> 20892</nlm:aff></affiliation></author><author><name sortKey="Hauser, David N" sort="Hauser, David N" uniqKey="Hauser D" first="David N." last="Hauser">David N. Hauser</name><affiliation><nlm:aff id="aff1">Cell Biology and Gene Expression Section,</nlm:aff></affiliation><affiliation><nlm:aff id="aff10">Brown University/National Institutes of Health Graduate Partnership Program, Department of Neuroscience,<institution>Brown University</institution>, Providence,<addr-line>RI</addr-line> 02912</nlm:aff></affiliation></author><author><name sortKey="Kumaran, Ravindran" sort="Kumaran, Ravindran" uniqKey="Kumaran R" first="Ravindran" last="Kumaran">Ravindran Kumaran</name><affiliation><nlm:aff id="aff1">Cell Biology and Gene Expression Section,</nlm:aff></affiliation></author><author><name sortKey="Lozano, Andres M" sort="Lozano, Andres M" uniqKey="Lozano A" first="Andres M." last="Lozano">Andres M. Lozano</name><affiliation><nlm:aff wicri:cut=", and" id="aff6">Division of Neurosurgery, Department of Surgery</nlm:aff><wicri:noCountry code="subfield">Department of Surgery</wicri:noCountry></affiliation></author><author><name sortKey="Baekelandt, Veerle" sort="Baekelandt, Veerle" uniqKey="Baekelandt V" first="Veerle" last="Baekelandt">Veerle Baekelandt</name><affiliation wicri:level="1"><nlm:aff id="aff8">Laboratory for Neurobiology and Gene Therapy,<institution>KU Leuven</institution>, 3000 Leuven,<country>Belgium</country>;</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Greene, Lois E" sort="Greene, Lois E" uniqKey="Greene L" first="Lois E." last="Greene">Lois E. Greene</name><affiliation><nlm:aff wicri:cut="; and" id="aff9">Laboratory of Cellular Physiology,<institution>National Heart, Lung and Blood Institute/National Institutes of Health</institution>, Bethesda,<addr-line>MD</addr-line> 20892</nlm:aff></affiliation></author><author><name sortKey="Taymans, Jean Marc" sort="Taymans, Jean Marc" uniqKey="Taymans J" first="Jean-Marc" last="Taymans">Jean-Marc Taymans</name><affiliation wicri:level="1"><nlm:aff id="aff8">Laboratory for Neurobiology and Gene Therapy,<institution>KU Leuven</institution>, 3000 Leuven,<country>Belgium</country>;</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Greggio, Elisa" sort="Greggio, Elisa" uniqKey="Greggio E" first="Elisa" last="Greggio">Elisa Greggio</name><affiliation wicri:level="1"><nlm:aff id="aff4">Department of Biology,<institution>University of Padova</institution>, 35131 Padua,<country>Italy</country>;</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Cookson, Mark R" sort="Cookson, Mark R" uniqKey="Cookson M" first="Mark R." last="Cookson">Mark R. Cookson</name><affiliation><nlm:aff id="aff1">Cell Biology and Gene Expression Section,</nlm:aff></affiliation></author></analytic><series><title level="j">Proceedings of the National Academy of Sciences of the United States of America</title><idno type="ISSN">0027-8424</idno><idno type="eISSN">1091-6490</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>Significance</title><p>Understanding loci nominated by genome-wide association studies (GWASs) is challenging. Here, we show, using the specific example of Parkinson disease, that identification of protein–protein interactions can help determine the most likely candidate for several GWAS loci. This result illustrates a significant general principle that will likely apply across multiple diseases.</p></div></front></TEI><affiliations><list><country><li>Belgique</li><li>Canada</li><li>Italie</li></country></list><tree><noCountry><name sortKey="Beilina, Alexandria" sort="Beilina, Alexandria" uniqKey="Beilina A" first="Alexandria" last="Beilina">Alexandria Beilina</name><name sortKey="Chau, Hien" sort="Chau, Hien" uniqKey="Chau H" first="Hien" last="Chau">Hien Chau</name><name sortKey="Chia, Ruth" sort="Chia, Ruth" uniqKey="Chia R" first="Ruth" last="Chia">Ruth Chia</name><name sortKey="Cookson, Mark R" sort="Cookson, Mark R" uniqKey="Cookson M" first="Mark R." last="Cookson">Mark R. Cookson</name><name sortKey="Ding, Jinhui" sort="Ding, Jinhui" uniqKey="Ding J" first="Jinhui" last="Ding">Jinhui Ding</name><name sortKey="Greene, Lois E" sort="Greene, Lois E" uniqKey="Greene L" first="Lois E." last="Greene">Lois E. Greene</name><name sortKey="Hauser, David N" sort="Hauser, David N" uniqKey="Hauser D" first="David N." last="Hauser">David N. Hauser</name><name sortKey="Kaganovich, Alice" sort="Kaganovich, Alice" uniqKey="Kaganovich A" first="Alice" last="Kaganovich">Alice Kaganovich</name><name sortKey="Kalia, Suneil K" sort="Kalia, Suneil K" uniqKey="Kalia S" first="Suneil K." last="Kalia">Suneil K. Kalia</name><name sortKey="Kumaran, Ravindran" sort="Kumaran, Ravindran" uniqKey="Kumaran R" first="Ravindran" last="Kumaran">Ravindran Kumaran</name><name sortKey="Lozano, Andres M" sort="Lozano, Andres M" uniqKey="Lozano A" first="Andres M." last="Lozano">Andres M. Lozano</name><name sortKey="Nalls, Mike A" sort="Nalls, Mike A" uniqKey="Nalls M" first="Mike A." last="Nalls">Mike A. Nalls</name><name sortKey="Ndukwe, Kelechi" sort="Ndukwe, Kelechi" uniqKey="Ndukwe K" first="Kelechi" last="Ndukwe">Kelechi Ndukwe</name><name sortKey="Olszewski, Maciej" sort="Olszewski, Maciej" uniqKey="Olszewski M" first="Maciej" last="Olszewski">Maciej Olszewski</name><name sortKey="Rudenko, Iakov N" sort="Rudenko, Iakov N" uniqKey="Rudenko I" first="Iakov N." last="Rudenko">Iakov N. Rudenko</name></noCountry><country name="Italie"><noRegion><name sortKey="Civiero, Laura" sort="Civiero, Laura" uniqKey="Civiero L" first="Laura" last="Civiero">Laura Civiero</name></noRegion><name sortKey="Greggio, Elisa" sort="Greggio, Elisa" uniqKey="Greggio E" first="Elisa" last="Greggio">Elisa Greggio</name></country><country name="Canada"><noRegion><name sortKey="Kalia, Lorraine V" sort="Kalia, Lorraine V" uniqKey="Kalia L" first="Lorraine V." last="Kalia">Lorraine V. Kalia</name></noRegion></country><country name="Belgique"><noRegion><name sortKey="Lobbestael, Evy" sort="Lobbestael, Evy" uniqKey="Lobbestael E" first="Evy" last="Lobbestael">Evy Lobbestael</name></noRegion><name sortKey="Baekelandt, Veerle" sort="Baekelandt, Veerle" uniqKey="Baekelandt V" first="Veerle" last="Baekelandt">Veerle Baekelandt</name><name sortKey="Taymans, Jean Marc" sort="Taymans, Jean Marc" uniqKey="Taymans J" first="Jean-Marc" last="Taymans">Jean-Marc Taymans</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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